Once an infestation is confirmed, the location of the nest needs to be determined. Many control products are effective against odorous ants; insecticide sprays or dust treatments can be applied directly to the nest or bait systems can be placed along their trails to eliminate any interior nests. Catching the infestation early dramatically improves the effectiveness of all control measures, as odorous ants can form large colonies in a short amount of time. Proper caution must be taken when handling and using pesticides, especially around children and animals, as many products are also dangerous to humans and pets.

To help prevent an infestation in the first place, seal all cracks and crevices into the home with caulk and trim plants and branches touching the structure. Large rocks near the home should also be moved, as odorous ants frequently construct nests underneath them.